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Furthermore, osthole pretreatment reversed APAP induced reduction of hepatic cAMP levels, but pretreatment with H89, a potent selective PKA inhibitor, failed to abolish the beneficial effect of osthole, whereas pretreatment with L buthionine sulfoximine, a GSH synthesis inhibitor, abrogated the protective effects of osthole on APAP induced liver injury, and abolished osthole caused alterations in APAP metabolizing enzymes nolvadex for sale amazon